Thermo Fisher
Orbitrap Velos Pro
Provisional entry — research in progress
This page was generated automatically from cited public sources and hasn't completed the full research pass yet. Every specification shown carries its source; more detail is added as research completes.
The Thermo Fisher Orbitrap Velos Pro is a hybrid mass spectrometer. The Thermo Fisher Orbitrap Velos Pro combines a Velos Pro dual-cell linear trap with an Orbitrap analyzer. The Thermo Fisher Orbitrap Velos Pro ETD mass spectrometer adds a reagent ion source for Electron Transfer Dissociation analyses.[1]
What it is
The Thermo Fisher Orbitrap Velos Pro is a hybrid mass spectrometer that combines a linear ion trap with an Orbitrap mass analyzer. The instrument belongs to the LTQ family of hybrid mass spectrometers.[1]
How it works
Where it fits in the process flow
General reference — not yet source-verifiedThe Orbitrap Velos Pro sits in an analytical measurement workflow after sample preparation and ionization. The instrument receives ions from an external source and performs mass analysis on the resulting ion population.
What do the numbers mean?
Power & electrical1
Gas & chemistry2
Optics & imaging4
- Resolution
- 60000 (FWHM) @ m/z 400 with a scan repetition rate of 1 second; minimum resolution 7500; maximum resolution 100000 @ m/z 400[1]
Performance2
- Mass accuracy
- <3 ppm RMS for 2 h period with external calibration using defined conditions; <1 ppm RMS with internal calibration[1]
Dimensions & facilities2
Configuration & options9
Vintage & configurations
Documented models & variants
| Designation | Generation | Vintage | Changes | Source |
|---|---|---|---|---|
| Orbitrap Velos Pro ETD | — | 2011 | ETD Module is physically coupled to the back of the Orbitrap Velos Pro mass spectrometer. | documents.thermofisher.com[1] |
What does it need to run?
Site utility requirements, footprint, and infrastructure needed to install and operate this tool. Sourced from public records.
- Power230 Vac ± 10% 3 phase, 15 Ampere, 50/60 Hz, with earth ground for the instrument[5]
- Helium gasUltra-high purity (99.999%) with less than 1 ppm each of water, oxygen and total hydrocarbons[5]
- Nitrogen gasHigh purity (99.5% pure, flow rate 15 L/min) nitrogen gas supply for the API source and the C-Trap[5]
Where are the manuals?
Generated from public-source data on file. Enter your email to access — nothing is published; details are routed privately.
Not publicly documented
Field notes
No research found yet — worked with this tool? Share what you know.
Frequently asked questions
What is the mass range of the Orbitrap Velos Pro?
The mass range is m/z 50–2,000 and m/z 200–4,000.[5]
What resolution can the instrument achieve?
The resolution is 60,000 at m/z 400 at a scan rate of 1 Hz, with a minimum resolution of 7,500 and a maximum resolution greater than 100,000 at m/z 400.[5]
What mass accuracy does the Orbitrap Velos Pro provide?
Mass accuracy is less than 3 ppm RMS with external calibration and less than 1 ppm RMS using internal calibration.[5]
What is the sensitivity specification for MS/MS?
Using electrospray ionization, injection of 2 μL of a 50 fg/μL solution of reserpine (100 femtograms total) at 500 μL/min produces a minimum signal-to-noise ratio of 100:1 for the transition of m/z 609 to m/z 397 and m/z 448 when operating at unit resolution in full-scan MS/MS mode.[5]
What is the dynamic range of the instrument?
The dynamic range is greater than 5,000 within a single scan, guaranteeing specified mass accuracy.[5]
What fragmentation techniques are available?
The instrument supports CID, HCD, and optionally ETD. The HCD collision cell includes an axial field gradient for improved efficiency.[5]
Not publicly documented
The following facts about the Orbitrap Velos Pro are absent from this record as of this revision. First-hand knowledge or a citation closes a gap; every submission is reviewed before publication.
The control-system platform and OS era of the Orbitrap Velos Pro are not on record.
Answerable by: an engineer who operated it or OEM installation records
No publicly documented failure modes or field errata for the Orbitrap Velos Pro are on record.
Answerable by: a field service engineer, process engineer, or maintenance technician
The process node or technology generation of the Orbitrap Velos Pro is not on record.
Answerable by: an OEM datasheet or a fab qualification report
No publicly documented compatible parts, consumables, or accessories for the Orbitrap Velos Pro are on record.
Answerable by: an OEM parts catalog or a service engineer
No publicly hosted manuals, SOPs, or datasheets for the Orbitrap Velos Pro are on record.
Answerable by: university cleanroom staff or an OEM application specialist
No research found yet — worked with this tool? Share what you know.
Sources & citations
Sources (5)Every fact above is drawn from these public sources
- [1]documents.thermofisher.com — documents.thermofisher.comdocuments.thermofisher.com
- [2]docs.thermofisher.com — docs.thermofisher.comdocs.thermofisher.com
- [3]Inventory photo
- [4]instrumenthive.cominstrumenthive.com
- [5]photos.labwrench.com — photos.labwrench.comphotos.labwrench.com
Last updated Oct 4, 2026.
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